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產(chǎn)品中心抗體/抗原流式抗體S0B5195APC Mouse Anti-Human CD105 Antibody (S-837-10)
產(chǎn)品型號：S0B5195
更新時間：2025-10-08
廠商性質：生產(chǎn)廠家
訪問量：90
服務熱線15855403091
產(chǎn)品分類
CD105, also known as endoglin, is a type I transmembrane glycoprotein predominantly expressed on endothelial cells and serves as an accessory receptor for the transforming growth factor-beta （TGF-β） superfamily. It plays a crucial role in angiogenesis, making it a key factor in tumor growth, survival, and metastasis. Structurally, CD105 is a homodimeric protein with a large extracellular domain, a hydrophobic transmembrane region, and a short cytoplasmic tail. Its expression is upregulated in proliferating endothelial cells, especially in tumor vessels, inflamed tissues, and during embryogenesis. Mutations in the CD105 gene are associated with hereditary hemorrhagic telangiectasia （HHT）, a disorder characterized by abnormal blood vessel formation. Due to its involvement in angiogenesis, CD105 has emerged as a potential therapeutic target for cancer treatment.
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