Alexa Fluor? 647 Rat Anti-Mouse CD226 Antibody (S-R625)

產(chǎn)品型號(hào)：S0B5017

更新時(shí)間：2025-10-08

廠商性質(zhì)：生產(chǎn)廠家

訪問量：92

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抗體/抗原

ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

CD226 （also known as DNAM-1） is a member of the immunoglobulin superfamily and is expressed on the surface of T cells, natural killer （NK） cells, monocytes, and macrophages. It enhances the activation, proliferation, and cytotoxic functions of T cells and NK cells by binding to its ligands CD155 and CD112 and activating downstream signaling pathways such as PI3K-AKT and VAV-1-ERK. CD226 plays a crucial role in anti-tumor immunity, with its high expression associated with better responses to immune checkpoint blockade therapies. However, its function can be inhibited by TIGIT, which competes with CD226 for binding to CD155, thereby dampening immune activation. CD226 is also involved in regulating the function of regulatory T cells （Tregs）, and its absence in Tregs can exacerbate inflammatory diseases. Thus, CD226 holds potential not only in cancer immunotherapy but also in the study of autoimmune diseases.

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